CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a revolutionary gene-editing technology that allows precise modifications in an organism’s DNA. It works with the Cas9 enzyme to cut specific DNA sequences, enabling the insertion, deletion, or correction of genes. CRISPR is significant because it offers a faster, cheaper, and more accurate method for genetic research compared to traditional techniques. Its applications include developing disease-resistant crops, treating genetic disorders like sickle cell anemia, and advancing cancer research. By transforming genetic engineering, CRISPR has opened new possibilities in medicine, agriculture, and synthetic biology, making it a cornerstone of modern biotechnology.